Initial study on TMPRSS2 p.Val160Met genetic variant in COVID-19 patients

Abstract Background Coronavirus disease 2019 (COVID-19) is a global health problem that causes millions of deaths worldwide. The clinical manifestation COVID-19 widely varies from asymptomatic infection to severe pneumonia and systemic inflammatory disease. It thought host genetic variability may affect the host’s response virus thus cause severity SARS-CoV-2 requires interaction with its receptor complex in cells before infection. transmembrane protease serine 2 (TMPRSS2) has been identified as one key molecules involved binding cell invasion. Therefore, this study, we investigated correlation between variant within human TMPRSS2 gene viral load. Results We genotyped 95 patients hospitalised Dr Soetomo General Hospital Indrapura Field (Surabaya, Indonesia) for p.Val160Met polymorphism. Polymorphism was detected using TaqMan assay. then analysed association presence did not observe any However, significant polymorphism load, estimated by Ct value diagnostic nucleic acid amplification test. Furthermore, observed trend C allele mortality rate COVID-19. Conclusion Our data indicate possible infectivity outcome